Doctor of Philosophy in Molecular and Cellular Pharmacology
Stony Brook University, In Progress
Bachelor of Science in Human Biology and Psychology
Minnesota State University, Mankato 2013
Ph.D. Thesis Project
Exploring the coordination of nuclear and mitochondrial genetic events at nucleoids and RNA granules.
Mentor: Daniel Bogenhagen, M.D.
Behavioral Medicine Division, Columbia University Medical Center
April 2014-August 2016
Aging, Cognition, and Exercise Study
A randomized, clinical trial comparing the effects of aerobic exercise and/or stretching/toning on cognitive function and brain structure. Study design involved the participant to adhere to assigned exercise group 4x/week for a 6 month intervention with multiple measures of cognition and neurological function being assessed at baseline, 3 months, and 6 months as well as inflammatory markers and fitness levels as measured by VO2max.
Grant Number: 1R01AG033546-01A2
Cocoa Flavanols and Memory Study
The purpose of this study is to examine the effect of dietary flavanols on brain activity in healthy older adults, ages 50-75.
Managed psychophysiology data scoring and processing from the MIDUS-R study (multi-site data collected at UCLA, Georgetown and UW Madison).
Minnesota State University, Mankato
Need for Higher Regulation of Second Generation Antipsychotics for BPSD
January 2013-April 2013
Awarded Best Presenter for my session at the 2013 Undergraduate Research Symposium at Minnesota State University, Mankato.
The review focused on the appropriateness of off-label use of second generation antipsychotics (SGA) as the treatment in the elderly for psychological and behavioral symptoms of dementia (BPSD) such as agitation. Currently, Beers Criteria by the American Geriatrics Society is the only reference for determining whether a prescription medication is a potentially inappropriate medication (PIM) for use in older adults. After reviewing Beers Criteria, the results indicated a specific need for further research into antipsychotics as PIMs. One major need identified was to differentiate between first-generation (FGA) and second-generation antipsychotics based on the large difference in their pharmacokinetic (PK) and pharmacodynamics (PD) properties. The articles reviewed focused on SGAs only; specifically olanzapine, risperidone, and aripiprazole. These drugs were selected because they have been observed to have small but statistically significant benefits in the off-label treatment of behavioral symptoms associated with dementia in elderly patients. Other articles reviewed, further identified areas that support the need for higher regulation of the prescribing rates beyond Beers Criteria. Specific areas of interest were articles on studies indicating an altered PK/PD model due to the decrease in drug metabolism, increased likelihood of polypharmacy, and increased comorbidity of diseases associated with age. The discussion emphasized the importance of these results and how they could be better indicated in Beers Criteria along with areas that need further exploration.
Mentor: Dr. Dawn Albertson, Psychology Department
Innate Defense System of Eisenia fetida
August 2011-March 2012
Utilized earthworm models to study innate immunity and to examine the role normal microbes have in the health and well-being of the worms. Focused on determining the mechanism the coelomic cells of E. fetida use to respond to invading microorganisms (instant kill v phagocytosis) and determine whether the coelomic cells are able to isolate invading bacteria from the normal microbiota. Employed various lab techniques including asepsis, collecting coelomic cells, culturing bacteria, enumerating bacteria (i.e. serial dilution, plate counts, use of spectrophotometer), identification of cells via staining, bright-field and fluorescent microscopy.
Mentor: Dr. Dorothy Wrigley, Biology Department
Herd Immunity and the Necessity of Vaccinations: Modeling the Effects of MMR Vaccinations
Jan 2010 – Apr 2010
Manipulated Microsoft Excel to mathematically model the importance of vaccines via projected herd
immunity associated with the MMR vaccine.
Mentors: Dr. Namyoung Lee, Mathematics Department and Dr. Marie-Anne Hoskinson, Biology Department
Bodin, F., Mcintyre, K. M., Schwartz, J. E., Mckinley, P. S., Cardetti, C., Shapiro, P. A., Gorenstein, E., Sloan, R. P. (2017). The Association of Cigarette Smoking With High-Frequency Heart Rate Variability. Psychosomatic Medicine, 79(9), 1045-1050. doi:10.1097/psy.0000000000000507
Cardetti, Caitlyn, Katie Groskreutz, and Melissa Zins. "Herd Immunity and the Necessity of Vaccinations: Modeling the Effects of MMR Vaccinations." Minnesota State University Mankato Journal of Undergraduate Research 10.1 (2010). Cornerstone. Minnesota State University Mankato. Download PDF here.